Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice and reveals a unique phenotype for pdpC.

@article{Long2013DisruptionOF,
  title={Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice and reveals a unique phenotype for pdpC.},
  author={Matthew E. Long and Stephen R. Lindemann and Jed A Rasmussen and Bradley D. Jones and Lee-Ann H Allen},
  journal={Infection and immunity},
  year={2013},
  volume={81 3},
  pages={
          850-61
        }
}
Francisella tularensis is a facultative intracellular bacterial pathogen and the causative agent of tularemia. After infection of macrophages, the organism escapes from its phagosome and replicates to high density in the cytosol, but the bacterial factors required for these aspects of virulence are incompletely defined. Here, we describe the isolation and characterization of Francisella tularensis subsp. tularensis strain Schu S4 mutants that lack functional iglI, iglJ, or pdpC, three genes of… CONTINUE READING
Highly Cited
This paper has 31 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

The Francisella Type VI Secretion System

Front. Cell. Infect. Microbiol. • 2018
View 7 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 46 references