Disruption of Dag1 in Differentiated Skeletal Muscle Reveals a Role for Dystroglycan in Muscle Regeneration

  title={Disruption of Dag1 in Differentiated Skeletal Muscle Reveals a Role for Dystroglycan in Muscle Regeneration},
  author={Ronald D. Cohn and M. David Henry and Daniel Eugene Michele and Rita Barresi and Fumiaki Saito and Steven A. Moore and Jason D. Flanagan and Mark W. Skwarchuk and Michael E. C. Robbins and Jerry R. Mendell and R Anthony Williamson and Kevin P Campbell},
Striated muscle-specific disruption of the dystroglycan (DAG1) gene results in loss of the dystrophin-glycoprotein complex in differentiated muscle and a remarkably mild muscular dystrophy with hypertrophy and without tissue fibrosis. We find that satellite cells, expressing dystroglycan, support continued efficient regeneration of skeletal muscle along with transient expression of dystroglycan in regenerating muscle fibers. We demonstrate a similar phenomenon of reexpression of functional… CONTINUE READING
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