Disruption of Dag1 in Differentiated Skeletal Muscle Reveals a Role for Dystroglycan in Muscle Regeneration

@article{Cohn2002DisruptionOD,
  title={Disruption of Dag1 in Differentiated Skeletal Muscle Reveals a Role for Dystroglycan in Muscle Regeneration},
  author={Ronald D. Cohn and M. David Henry and Daniel Eugene Michele and Rita Barresi and Fumiaki Saito and Steven A. Moore and Jason D. Flanagan and Mark W. Skwarchuk and Michael E. C. Robbins and Jerry R. Mendell and R Anthony Williamson and Kevin P Campbell},
  journal={Cell},
  year={2002},
  volume={110},
  pages={639-648}
}
Striated muscle-specific disruption of the dystroglycan (DAG1) gene results in loss of the dystrophin-glycoprotein complex in differentiated muscle and a remarkably mild muscular dystrophy with hypertrophy and without tissue fibrosis. We find that satellite cells, expressing dystroglycan, support continued efficient regeneration of skeletal muscle along with transient expression of dystroglycan in regenerating muscle fibers. We demonstrate a similar phenomenon of reexpression of functional… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
104 Citations
22 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 104 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Disruptionanalyzed statistically using Student ’ s t test . of the sarcoglycan gene reveals a complex pathogenetic mechansim for LGMD 2 E

  • M. Durbeej, R. D. Cohn, +5 authors K. P. Campbell
  • Mol . Cell
  • 2000
Highly Influential
3 Excerpts

Epiblast - restricted Cre excular dystrophy

  • R. D. Cohn, S. A. Moore, J. A. Hill, R. M. Weiss
  • Muscle Nerve
  • 2000

Fetal and adult hematopoietic stem cells require beta 1 integrin function forinsulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

  • Y. Sunada, S. M. Bernier, C. A. Kozak, Y. Yamada, K. P. Campbell
  • Mol . Cell 2 , colonizing fetal liver , spleen…
  • 2000

How calcium influx

  • J. M. Alderton, R. A. Steinhardt
  • 2000
1 Excerpt

Similar Papers

Loading similar papers…