Disruption of Ca2+ homeostasis in Trypanosoma cruzi by crystal violet.

@article{Docampo1993DisruptionOC,
  title={Disruption of Ca2+ homeostasis in Trypanosoma cruzi by crystal violet.},
  author={Roberto Docampo and Fernanda Ramos Gadelha and Sol Naranjo Moreno and Gustavo Benaim and Manuel Hoffmann and Anibal E Vercesi},
  journal={The Journal of eukaryotic microbiology},
  year={1993},
  volume={40 3},
  pages={311-6}
}
We have demonstrated previously that crystal violet induces a rapid, dose-related collapse of the inner mitochondrial membrane potential of Trypanosoma cruzi epimastigotes. In this work, we show that crystal violet-induced dissipation of the membrane potential was accompanied by an efflux of Ca2+ from the mitochondria. In addition, crystal violet inhibited… CONTINUE READING