Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

@article{Highfill2014DisruptionOC,
  title={Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy},
  author={Steven L Highfill and Yongzhi K. Cui and Amber J Giles and Jillian P. Smith and Hua Zhang and Elizabeth M. Morse and Rosandra N. Kaplan and Crystal L Mackall},
  journal={Science Translational Medicine},
  year={2014},
  volume={6},
  pages={237ra67-237ra67}
}
Suppression of the host’s immune system plays a major role in cancer progression. Tumor signaling of programmed death 1 (PD1) on T cells and expansion of myeloid-derived suppressor cells (MDSCs) are major mechanisms of tumor immune escape. We sought to target these pathways in rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood. Murine RMS showed high surface expression of PD-L1, and anti-PD1 prevented tumor growth if initiated early after tumor inoculation; however… CONTINUE READING
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