Disruption of CTCF at the miR-125b1 locus in gynecological cancers and breast cancer cell lines

@inproceedings{SotoReves2011DisruptionOC,
  title={Disruption of CTCF at the miR-125b1 locus in gynecological cancers and breast cancer cell lines},
  author={Ernesto Soto-Reves and Fernanda Cisneros-Soberanis and Iliana Alcal{\'a} Moreno and Rodrigo Gonza{\'i}lez Barrios and David Francisco Cant{\'u} de Le{\'o}n and Clementina H Castro and Luis Alonso Herrera},
  booktitle={Epigenetics & Chromatin},
  year={2011}
}
In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. The disruption of DNA methylation patterns and covalent histone marks has been associated with cancer development. Until recently, microRNA (miRNA) gene silencing was not well understood. In particular, miR-125b1 has been suggested to be an miRNA with tumor suppressor activity, and it has been shown to be deregulated in various human cancers. In the present study, we evaluated the DNA… CONTINUE READING

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