Disruption of CREB function in brain leads to neurodegeneration

@article{Mantamadiotis2002DisruptionOC,
  title={Disruption of CREB function in brain leads to neurodegeneration},
  author={Theo Mantamadiotis and Thomas Lemberger and Susanne C. Bleckmann and Heidrun Kern and Oliver Kretz and Ana Villalba and François Tronche and Christoph Kellendonk and Daniel Gau and Josef P. Kapfhammer and Christiane Otto and Wolfgang Schmid and Günther Schütz},
  journal={Nature Genetics},
  year={2002},
  volume={31},
  pages={47-54}
}
Control of cellular survival and proliferation is dependent on extracellular signals and is a prerequisite for ordered tissue development and maintenance. Activation of the cAMP responsive element binding protein (CREB) by phosphorylation has been implicated in the survival of mammalian cells. To define its roles in the mouse central nervous system, we disrupted Creb1 in brain of developing and adult mice using the Cre/loxP system. Mice with a Crem−/− background and lacking Creb in the central… Expand
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