Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection.

@article{Soong1996DisruptionOC,
  title={Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection.},
  author={Lynn Soong and J. C. Xu and Iqbal S. Grewal and Peter E Kima and J Sun and B. Jack Longley and Nancy H. Ruddle and Diane M. McMahon-Pratt and Richard A Flavell},
  journal={Immunity},
  year={1996},
  volume={4 3},
  pages={
          263-73
        }
}
To study the role of CD40 ligand (CD40L) in the host immune responses against intracellular pathogens, we infected CD40L knockout (CD40L-/-) mice with Leishmania amazonensis. Although wild-type mice were susceptible to infection and developed progressive ulcerative lesions, tissue parasite burdens in CD40L-/- mice were significantly higher. This heightened susceptibility to infection was associated with an impaired T cell and macrophage activation and altered inflammatory response, as reflected… CONTINUE READING

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