Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo.

@article{Patel2007DisruptionOC,
  title={Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo.},
  author={Samir N. Patel and Ziyue Lu and Kodjo Ayi and Lena Serghides and D Channe Gowda and Kevin C Kain},
  journal={Journal of immunology},
  year={2007},
  volume={178 6},
  pages={3954-61}
}
CD36 is a scavenger receptor that has been implicated in malaria pathogenesis as well as innate defense against blood-stage infection. Inflammatory responses to Plasmodium falciparum GPI (pfGPI) anchors are believed to play an important role in innate immune response to malaria. We investigated the role of CD36 in pfGPI-induced MAPK activation and proinflammatory cytokine secretion. Furthermore, we explored the role of this receptor in an experimental model of acute malaria in vivo. We… CONTINUE READING