Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance.

@article{She2010DisruptionOB,
  title={Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance.},
  author={Pengxiang She and Yingsheng Zhou and Zhiyou Zhang and Kathleen Griffin and Kavitha Gowda and Christopher J. Lynch},
  journal={Journal of applied physiology},
  year={2010},
  volume={108 4},
  pages={
          941-9
        }
}
  • Pengxiang She, Yingsheng Zhou, +3 authors Christopher J. Lynch
  • Published in Journal of applied physiology 2010
  • Chemistry, Medicine
  • Exercise enhances branched-chain amino acid (BCAA) catabolism, and BCAA supplementation influences exercise metabolism. However, it remains controversial whether BCAA supplementation improves exercise endurance, and unknown whether the exercise endurance effect of BCAA supplementation requires catabolism of these amino acids. Therefore, we examined exercise capacity and intermediary metabolism in skeletal muscle of knockout (KO) mice of mitochondrial branched-chain aminotransferase (BCATm… CONTINUE READING

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