Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance

@inproceedings{Vazirani2016DisruptionOA,
  title={Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance},
  author={Reema P. Vazirani and Akanksha Verma and Leigh Amanda Sadacca and Melanie S. Buckman and Bel{\'e}n Picatoste and Muheeb Beg and Christopher Torsitano and Joanne H. Bruno and Rajesh Tulsibhai Patel and Kotryna Simonyte and Jo{\~a}o Paulo Camporez and Gabriela Virg{\'i}nia Moreira and Domenick J. Falcone and Domenico Accili and Ashutosh Kumar Tewari and Gerald I Shulman and Barbara B Kahn and Timothy E McGraw},
  booktitle={Diabetes},
  year={2016}
}
Insulin controls glucose uptake into adipose and muscle cells by regulating the amount of GLUT4 in the plasma membrane. The effect of insulin is to promote the translocation of intracellular GLUT4 to the plasma membrane. The small Rab GTPase, Rab10, is required for insulin-stimulated GLUT4 translocation in cultured 3T3-L1 adipocytes. Here we demonstrate that both insulin-stimulated glucose uptake and GLUT4 translocation to the plasma membrane are reduced by about half in adipocytes from adipose… CONTINUE READING
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