Disruption in neuropeptide Y and leptin signaling in obese ventromedial hypothalamic-lesioned rats.

@article{Dube1999DisruptionIN,
  title={Disruption in neuropeptide Y and leptin signaling in obese ventromedial hypothalamic-lesioned rats.},
  author={Michael G. Dube and Bin Xu and Pushpa S. Kalra and Charles A. Sninsky and Satya P. Kalra},
  journal={Brain research},
  year={1999},
  volume={816 1},
  pages={38-46}
}
Electrolytic lesions placed in the ventromedial hypothalamus (VMH) of rats induce instant hyperphagia and excessive weight gain. Since neuropeptide Y (NPY) is a potent hypothalamic orexigenic signal, and leptin secreted by adipocytes regulates NPY output, we tested the hypothesis that altered NPYergic-leptin signaling may underlie hyperphagia in VMH-lesioned rats. VMH-lesioned rats exhibiting hyperphagia and excessive weight gain in a time-related fashion were sacrificed on days 2, 7, and 21… CONTINUE READING
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