Disrupting the interaction between HOX and PBX causes necrotic and apoptotic cell death in the renal cancer lines CaKi-2 and 769-P.

@article{Shears2008DisruptingTI,
  title={Disrupting the interaction between HOX and PBX causes necrotic and apoptotic cell death in the renal cancer lines CaKi-2 and 769-P.},
  author={Liesl Shears and Lynn Plowright and Kevin Harrington and Hardev S. Pandha and R Garret Morgan},
  journal={The Journal of urology},
  year={2008},
  volume={180 5},
  pages={2196-201}
}
PURPOSE The HOX genes are a family of homeodomain containing transcription factors that determine embryonic tissue identity and also have regulatory and oncogenic roles in adult cells. We quantified the expression of HOX genes in normal kidney tissue, primary tumors and derived cell lines, and examined their role in renal cancer cell survival. MATERIALS AND METHODS Quantitative polymerase chain reaction was used to evaluate HOX gene expression in cells and tissues. HOX gene function was… CONTINUE READING

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