Disrupting the establishment of polarizing activity by teratogen exposure


Between days 9.5 and 10, the forelimb buds of developing murine embryos progress from stage 1 which are just beginning to express shh and whose posterior mesoderm has only weak polarizing activity to stage 2 limbs with a distinguishable shh expression domain and full polarizing activity. We find that exposure on day 9.5 to teratogens that induce the loss of… (More)
DOI: 10.1016/S0925-4773(99)00181-1


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