Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development.

@article{Whisenhunt2006DisruptingTE,
  title={Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development.},
  author={Thomas R. Whisenhunt and Xiaoyong Yang and Damon B. Bowe and Andrew W J Paterson and Brian Andrew Van Tine and Jeffrey E. Kudlow},
  journal={Glycobiology},
  year={2006},
  volume={16 6},
  pages={551-63}
}
Although the knowledge that nuclear and cytoplasmic proteins are modified with N-acetylglucosamine has existed for decades, little has been shown as to its function until recently. There are now substantial data highlighting the significance of proper regulation of this modification in multiple cellular processes. Currently, only two enzymes are known that regulate this modification. O-GlcNAc transferase (OGT) modifies protein substrates posttranslationally by adding the N-acetylglucosamine… CONTINUE READING

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