Disrupted white matter integrity in first-episode, drug-naive, late-onset depression.

@article{Guo2014DisruptedWM,
  title={Disrupted white matter integrity in first-episode, drug-naive, late-onset depression.},
  author={Wenbin Guo and Feng Liu and Guanglei Xun and Maorong Hu and Xiaofeng Guo and Changqing Xiao and Huafu Chen and Jindong Chen and Jingping Zhao},
  journal={Journal of affective disorders},
  year={2014},
  volume={163},
  pages={
          70-5
        }
}
BACKGROUND Abnormalities of white matter integrity in frontal and limbic regions have been postulated to play a key role in the pathophysiology of geriatric depression. However, there is no diffusion tensor imaging (DTI) study in patients with first-episode, drug-naive, late-onset depression (LOD). The aim of this study was to investigate whole-brain fractional anisotropy (FA) difference between patients with LOD and healthy controls without a previously determined region of interest. METHODS… CONTINUE READING
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