Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death.

@article{Colton2004DisruptedSH,
  title={Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death.},
  author={Carol A. Colton and Qing Xu and J. Richard Burke and S Y Bae and John K. Wakefield and A. Radhakrishnan Nair and Warren J. Strittmatter and Michael P Vitek},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 32},
  pages={
          7118-27
        }
}
  • Carol A. Colton, Qing Xu, +5 authors Michael P Vitek
  • Published in
    The Journal of neuroscience…
    2004
  • Biology, Medicine
  • Our data suggest a novel mechanism whereby pathological-length polyglutamine (polyQ) proteins promote the spermine synthetic pathway, increasing polyQ-aggregation and cell death. As detected in a cell-free turbidity assay, spermine promotes aggregation of thio-polyQ62 in a dose-dependent manner. Using a stable neuronal cell line expressing pathological-length [polyQ57-yellow fluorescent protein (YFP) (Q57)] or non-pathological-length [polyQ19-YFP (Q19)] polyglutamine protein, we show that… CONTINUE READING

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