Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology.

@article{Yang2001DisruptedSA,
  title={Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology.},
  author={Shiqi Yang and Hui Zhi Lin and Asim K. Mandal and Jiawen Huang and Anna Mae Diehl},
  journal={Hepatology},
  year={2001},
  volume={34 4 Pt 1},
  pages={694-706}
}
The impaired regenerative capacity of fatty livers might promote the progression of nonalcoholic fatty liver disease (NAFLD). To identify mechanisms involved, regenerative responses were compared in normal mice and ob/ob mice (a model for NAFLD) after partial hepatectomy (PH). We hypothesized that the usual PH activation of oxidant-sensitive, growth-regulatory kinase cascades would be abnormal in fatty hepatocytes, which have adapted to chronic oxidant stress, and expected that this might… CONTINUE READING

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