Disrupted neuronal activity rhythms in the suprachiasmatic nuclei of vasoactive intestinal polypeptide-deficient mice.

@article{Brown2007DisruptedNA,
  title={Disrupted neuronal activity rhythms in the suprachiasmatic nuclei of vasoactive intestinal polypeptide-deficient mice.},
  author={Timothy M Brown and Christopher S Colwell and James A. Waschek and Hugh D. Piggins},
  journal={Journal of neurophysiology},
  year={2007},
  volume={97 3},
  pages={2553-8}
}
Vasoactive intestinal polypeptide (VIP), acting via the VPAC(2) receptor, is a key signaling pathway in the suprachiasmatic nuclei (SCN), the master clock controlling daily rhythms in mammals. Most mice lacking functional VPAC(2) receptors are unable to sustain behavioral rhythms and lack detectable SCN electrical rhythms in vitro. Adult mice that do not… CONTINUE READING