Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders.

  title={Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders.},
  author={Christina N. Vallianatos and Shigeki Iwase},
  volume={7 3},
Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci. Recent advances in next-generation sequencing have identified a number of H3K4me regulators mutated in neurodevelopmental disorders including intellectual disabilities, autism spectrum disorders, and schizophrenia. Here, we aim to summarize the molecular function of H3K4me-regulating enzymes in… CONTINUE READING
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