Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness.

@article{Millar2007DisruptedIS,
  title={Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness.},
  author={Jessica K Millar and Shaun Mackie and Steven J Clapcote and Hannah Murdoch and Ben S. Pickard and S. Christie and Walter J. Muir and Douglas H. R. Blackwood and John C. C. Roder and Miles D Houslay and David J. Porteous},
  journal={The Journal of physiology},
  year={2007},
  volume={584 Pt 2},
  pages={401-5}
}
Disrupted in schizophrenia 1 (DISC1) is one of the most convincing genetic risk factors for major mental illness identified to date. DISC1 interacts directly with phosphodiesterase 4B (PDE4B), an independently identified risk factor for schizophrenia. DISC1-PDE4B complexes are therefore likely to be involved in molecular mechanisms underlying psychiatric illness. PDE4B hydrolyses cAMP and DISC1 may regulate cAMP signalling through modulating PDE4B activity. There is evidence that expression of… CONTINUE READING