Disrupted in Schizophrenia 1 forms pathological aggresomes that disrupt its function in intracellular transport.

@article{Atkin2012DisruptedIS,
  title={Disrupted in Schizophrenia 1 forms pathological aggresomes that disrupt its function in intracellular transport.},
  author={Talia A. Atkin and Nicholas J. Brandon and Josef T Kittler},
  journal={Human molecular genetics},
  year={2012},
  volume={21 9},
  pages={2017-28}
}
Disrupted in Schizophrenia 1 (DISC1) is a key susceptibility gene implicated in major mental illnesses, such as schizophrenia, depression, bipolar disorder and autism, but the link between this protein and the pathology of these diseases remains unclear. Recently, DISC1 has been demonstrated to form insoluble protein aggregates in vitro and in human post-mortem brain tissue but the cellular dynamics of these DISC1 aggregates and their effects on neuronal function are unknown. Using a… CONTINUE READING
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Common DISC 1 polymorphisms disrupt Wnt / GSK 3 beta signaling and brain development

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Common DISC1 polymorphisms disrupt Wnt/GSK3beta signaling and brain

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