Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

@article{Mao2009DisruptedIS,
  title={Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling},
  author={Yingwei Mao and Xuecai Ge and Christopher L. Frank and J. Mark Madison and Angela N. Koehler and Mary Kathryn Doud and Carlos Tassa and Erin M. Berry and Takahiro Soda and Karun K Singh and Travis L. Biechele and Tracey L. Petryshen and Randall T. Moon and Stephen J. Haggarty and Li-Huei Tsai},
  journal={Cell},
  year={2009},
  volume={136},
  pages={1017-1031}
}
The Disrupted in Schizophrenia 1 (DISC1) gene is disrupted by a balanced chromosomal translocation (1; 11) (q42; q14.3) in a Scottish family with a high incidence of major depression, schizophrenia, and bipolar disorder. Subsequent studies provided indications that DISC1 plays a role in brain development. Here, we demonstrate that suppression of DISC1 expression reduces neural progenitor proliferation, leading to premature cell cycle exit and differentiation. Several lines of evidence suggest… CONTINUE READING
Highly Influential
This paper has highly influenced 43 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
350 Extracted Citations
45 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 350 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 45 references

Similar Papers

Loading similar papers…