Disrupted hippocampal sharp-wave ripple-associated spike dynamics in a transgenic mouse model of dementia.

@article{Witton2016DisruptedHS,
  title={Disrupted hippocampal sharp-wave ripple-associated spike dynamics in a transgenic mouse model of dementia.},
  author={Jonathan Witton and Lydia E Staniaszek and Ullrich Bartsch and Andrew D Randall and Matthew W. Jones and Jonathan T Brown},
  journal={The Journal of physiology},
  year={2016},
  volume={594 16},
  pages={4615-30}
}
KEY POINTS High frequency (100-250 Hz) neuronal oscillations in the hippocampus, known as sharp-wave ripples (SWRs), synchronise the firing behaviour of groups of neurons and play a key role in memory consolidation. Learning and memory are severely compromised in dementias such as Alzheimer's disease; however, the effects of dementia-related pathology on SWRs are unknown. The frequency and temporal structure of SWRs was disrupted in a transgenic mouse model of tauopathy (one of the major… CONTINUE READING

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