Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection.

@article{Blakely2009DisruptedGT,
  title={Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection.},
  author={Pennelope K Blakely and Bette K Kleinschmidt-DeMasters and Kenneth L. Tyler and David N. Irani},
  journal={Journal of neuropathology and experimental neurology},
  year={2009},
  volume={68 10},
  pages={1061-72}
}
Neuroinvasive West Nile virus (WNV) infections may cause acute flaccid paralysis (AFP); in fatal cases, anterior horn cell loss is presumed to be caused by direct viral infection. In related animal models, however, glutamate excitotoxicity mediates bystander injury of uninfected anterior horn cells, suggesting additional pathogenic mechanisms. We examined expression of the principal excitatory amino acid transporter (EAAT) of astrocytes (i.e. EAAT-2 in humans, glutamate transporter 1 in… CONTINUE READING
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West Nile virusYassociated acute flaccid paralysis

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Highly Influential
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