Disrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency (cmd) mutant.

Abstract

Chondrodysplasia in the autosomal recessive cartilage matrix deficiency (cmd) mutant is caused by lack of the proteoglycan aggrecan arising from a mutation in the gene. Homozygous cmd/cmd mice are characterized by disorganisation of chondrocytes in the growth plate, disproportionate dwarfism, cleft palate, and perinatal lethality. We have studied the impact… (More)

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Cite this paper

@article{Wai1998DisruptedEO, title={Disrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency (cmd) mutant.}, author={Albert W. K. Wai and L J Ng and Hiroki Watanabe and Y. Yamada and P P Tam and K. S. Cheah}, journal={Developmental genetics}, year={1998}, volume={22 4}, pages={349-58} }