Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex.

@article{Mallet2008DisruptedDT,
  title={Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex.},
  author={Nicolas Mallet and Alek Pogosyan and Andrew Sharott and Jozsef Csicsvari and J. Paul Bolam and Peter Brown and Peter J. Magill},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 18},
  pages={
          4795-806
        }
}
In the subthalamic nucleus (STN) of Parkinson's disease (PD) patients, a pronounced synchronization of oscillatory activity at beta frequencies (15-30 Hz) accompanies movement difficulties. Abnormal beta oscillations and motor symptoms are concomitantly and acutely suppressed by dopaminergic therapies, suggesting that these inappropriate rhythms might also emerge acutely from disrupted dopamine transmission. The neural basis of these abnormal beta oscillations is unclear, and how they might… CONTINUE READING
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