Disrupted calcium homeostasis is involved in elevated zinc ion-induced photoreceptor cell death.

@article{Guo2014DisruptedCH,
  title={Disrupted calcium homeostasis is involved in elevated zinc ion-induced photoreceptor cell death.},
  author={Dadong Guo and Yuxiang Du and Qiuxin Wu and Wenjun Jiang and Hongsheng Bi},
  journal={Archives of biochemistry and biophysics},
  year={2014},
  volume={560},
  pages={44-51}
}
Zinc (Zn), the second abundant trace element in living organisms, plays an important role in regulating cell metabolism, signaling, proliferation, gene expression and apoptosis. Meanwhile, the overload of Zn will disrupt the intracellular calcium homeostasis via impairing mitochondrial function. However, the specific molecular mechanism underlying zinc-induced calcium regulation remains poorly understood. In the present study, using zinc chloride (ZnCl2) as a stressor, we investigated the… CONTINUE READING