Corpus ID: 15262907

Disrupted brain thyroid hormone homeostasis and altered thyroid hormone-dependent brain gene expression in autism spectrum disorders.

@article{Khan2014DisruptedBT,
  title={Disrupted brain thyroid hormone homeostasis and altered thyroid hormone-dependent brain gene expression in autism spectrum disorders.},
  author={A. Khan and J. Harney and A. Zavacki and E. Sajdel-Sulkowska},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2014},
  volume={65 2},
  pages={
          257-72
        }
}
  • A. Khan, J. Harney, +1 author E. Sajdel-Sulkowska
  • Published 2014
  • Biology, Medicine
  • Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
The present study examined human postmortem brains for changes consistent with the hypothesis of local brain TH deficiency in autism spectrum disorders (ASD). Brain levels of oxidative stress marker - 3-nitrotyrosine (3-NT), iodothyronine deiodinase type 2(D2) and type 3 (D3), 3',3,5-triiodothyronine (T3) content, mercury content and gene expression levels were analyzed and compared in the several regions of postmortem brains derived from both male and female control and ASD cases, age 4-16… Expand
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24 Citations

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Citation Type

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Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders
Adult onset of type 3 deiodinase deficiency in mice alters brain gene expression and increases locomotor activity
Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease
Induction of hypothyroidism during early postnatal stages triggers a decrease in cognitive performance by decreasing hippocampal synaptic plasticity.
Implications of prenatal steroid perturbations for neurodevelopment, behavior, and autism.
The relationship between mercury and autism: A comprehensive review and discussion.
Solving for X: evidence for sex-specific autism biomarkers across multiple transcriptomic studies
Variation in Gene Expression in Autism Spectrum Disorders: An Extensive Review of Transcriptomic Studies
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References

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