Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: Impact of mouse models

  title={Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: Impact of mouse models},
  author={Tatiana V. Lipina and John C. C. Roder},
  journal={Neuroscience & Biobehavioral Reviews},
Disrupted-In-Schizophrenia-1 (DISC1) has captured much attention because it predisposes individuals to a wide range of mental illnesses. Notably, a number of genes encoding proteins interacting with DISC1 are also considered to be relevant risk factors of mental disorders. We reasoned that the understanding of DISC1-associated mental disorders in the context of network principles will help to address fundamental properties of DISC1 as a disease gene. Systematic integration of behavioural… CONTINUE READING
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