Disposition of valpromide, valproic acid, and valnoctamide in the brain, liver, plasma, and urine of rats.

@article{Blotnik1996DispositionOV,
  title={Disposition of valpromide, valproic acid, and valnoctamide in the brain, liver, plasma, and urine of rats.},
  author={Simcha Blotnik and Felix Bergman and Meir Bialer},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1996},
  volume={24 5},
  pages={560-4}
}
Valpromide (VPD) and valnoctamide (VCD) are amide derivatives of valproic acid (VPA), one of the major antiepileptic drugs (AEDs). In rodent models, both VPD and VCD are more potent as anticonvulsants than VPA. However, in humans, VPD served as a prodrug to VPA, whereas VCD acts as a drug on its own, which is not biotransformed to its corresponding acid--valnoctic acid (VCA). The present study investigates the pharmacokinetics (PKs of VPD and VCD in rats by monitoring the levels of these two… CONTINUE READING

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