Disposition of sumatriptan in laboratory animals and humans.

@article{Dixon1993DispositionOS,
  title={Disposition of sumatriptan in laboratory animals and humans.},
  author={C M Dixon and D. A. Saynor and P D Andrew and Janet Oxford and A. Bradbury and Michael H. Tarbit},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1993},
  volume={21 5},
  pages={761-9}
}
Sumatriptan is a new 5HT1-like agonist that has proved a novel and effective treatment for migraine. The disposition of the 14C-radiolabeled drug in laboratory animals and humans after oral and parenteral administration is described. Oral absorption of sumatriptan is essentially complete in dogs and rabbits, but only approximately 50% in rat. In humans, at least 57% of an oral dose is absorbed. Bioavailabilities are species dependent (14, 23, 37, and 58% in humans, rabbits, rats, and dogs… CONTINUE READING

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