Disposition of prednisone and prednisolone in the perfused rabbit liver: Modeling hepatic metabolic processes

  title={Disposition of prednisone and prednisolone in the perfused rabbit liver: Modeling hepatic metabolic processes},
  author={V. G. Hale and Kazumasa Aizawa and Lewis B. Sheiner and Leslie Z. Benet},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  • V. Hale, K. Aizawa, L. Benet
  • Published 1 October 1991
  • Biology, Medicine
  • Journal of Pharmacokinetics and Biopharmaceutics
The livers of 15 rabbits were perfused in situwith prednisone (PO) or prednisolone (POH) over a wide range of steady state concentrations, resulting in multiple experimental measurements per organ. Linearity of extraction, an apparent lack of oxidative conversion, and marked preference for the reduction of PO to POH was observed. Predictions of hepatic tissue concentrations were made using both the well-stirred and parallel-tube model approximations. Giucocorticoid disposition across the liver… 
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  • K. PangM. Rowland
  • Biology, Medicine
    Journal of Pharmacokinetics and Biopharmaceutics
  • 2005
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