Disposition of perfluorodecanoic acid in male and female rats.

  title={Disposition of perfluorodecanoic acid in male and female rats.},
  author={John Patrick Vanden Heuvel and B. I. Kuslikis and M J Van Rafelghem and Richard Einer Peterson},
  journal={Toxicology and applied pharmacology},
  volume={107 3},
The elimination, tissue distribution, and metabolism of [1-14C]PFDA were examined in male and female rats for 28 days after a single ip dose (9.4 mumol/kg, 5 mg/kg). A sex difference in the fecal elimination of perfluorodecanoic acid (PFDA) was observed with 51 and 24% of the administered 14C being recovered in the feces of male and female rats, respectively, by 28 days post-treatment. The cumulative excretion of PFDA-derived 14C in the urine in 28 days was less than 5% of the administered dose… CONTINUE READING
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