Disposition of metformin (N,N‐dimethylbiguanide) in man

@article{Sirtori1978DispositionOM,
  title={Disposition of metformin (N,N‐dimethylbiguanide) in man},
  author={Cesare R. Sirtori and Guido Franceschini and M. Galli-Kienle and Giuliana Cighetti and Giovanni Galli and Alighiero Bondioli and F. Conti},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1978},
  volume={24}
}
Kinetic parameters ol metformin (N,N‐dimethylbiguanide), an anti‐diabetic reported to be associated with a lower number of episodes of lactic acidosis than phenformin, were determined in volunteers with normal renal function and in patients with different degrees ol renal impairment. Drug in body fluids was measured by a highly specific and sensitive mass fragmentographic method, alter the formation of a triazine derivative, obtained with heptafluorobutyric anhydride. The half‐life (t½) for the… Expand
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