Disposition of genistein in rainbow trout (Oncorhynchus mykiss) and siberian sturgeon (Acipenser baeri).

@article{GontierLatonnelle2007DispositionOG,
  title={Disposition of genistein in rainbow trout (Oncorhynchus mykiss) and siberian sturgeon (Acipenser baeri).},
  author={K Gontier-Latonnelle and J P Crav{\'e}di and Michel Laurentie and Elisabeth Perdu and Val{\'e}rie Lamothe and Françoise Le Menn and Catherine Bennetau-Pelissero},
  journal={General and comparative endocrinology},
  year={2007},
  volume={150 2},
  pages={298-308}
}
Genistein (G) is a xenoestrogen from soy present in fish diet. In vivo, a 50-fold difference in sensitivity to genistein on vitellogenin (VTG) synthesis was found when comparing trout and sturgeon. This difference was not linked to the estrogen receptor affinity nor to the sensitivity of induction of the VTG pathway. The study was performed to check if differences in the G disposition in the two species could explain their difference of sensitivity to G. A pharmacokinetic analysis of… CONTINUE READING

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