Disposition of chiral and racemic fluoxetine and norfluoxetine across childbearing.

OBJECTIVE To add to the limited data on the clinical pharmacology of antidepressants during pregnancy, we examined the dose-corrected chiral and racemic levels (level/dose) of fluoxetine (FLX) and norfluoxetine (NorFLX) during pregnancy and early postpartum. METHODS The authors evaluated 17 pregnant women who received fluoxetine therapy. Doses were… CONTINUE READING