Disposition of catecholamine-derived alkaloids in mammalian systems.

  title={Disposition of catecholamine-derived alkaloids in mammalian systems.},
  author={V E Davis and J L Cashaw and Kenneth D. McMurtrey},
  journal={Advances in experimental medicine and biology},
Tetrahydropapaveroline, the tetrahydroisoquinoline alkaloid derived from dopamine, is converted in vivo by rats and by rat liver and brain preparations to tetrahydroprotoberberine alkaloids. The latter alkaloids have also been identified for the first time in the urine of parkinsonian patients receiving L-dopa therapy. These findings suggest that man, like plants, may have the ability to elaborate several classes of alkaloids with potentially important pharmacological consequences. Thus, this… CONTINUE READING