Disposition of azapropazone in chronic renal and hepatic failure


The disposition of azapropazone 600 mg i.v. was investigated in 6 healthy subjects, 13 patients with cirrhosis and 8 patients with renal failure. In healthy subjects the elimination half-life was 12.2±2.1 h (mean ± SD), the volume of distribution 10.6±3.31 and the total clearance was 597±135 ml·h−1. Renal clearance accounted for about 62% of the total… (More)
DOI: 10.1007/BF00607152


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@article{Breuing1981DispositionOA, title={Disposition of azapropazone in chronic renal and hepatic failure}, author={K. -H. Breuing and H. -J. Gilfrich and Th. Meinertz and U. -W. Wiegand and Eberhard J{\"a}hnchen}, journal={European Journal of Clinical Pharmacology}, year={1981}, volume={20}, pages={147-155} }