Disposition of Extended Release Levetiracetam in Normal Healthy Dogs After Single Oral Dosing

@inproceedings{Beasley2015DispositionOE,
  title={Disposition of Extended Release Levetiracetam in Normal Healthy Dogs After Single Oral Dosing},
  author={M. Beasley and D. Boothe},
  booktitle={Journal of veterinary internal medicine},
  year={2015}
}
BACKGROUND Levetiracetam is an anticonvulsant used for control of canine epilepsy. An extended release preparation should improve dosing convenience. OBJECTIVES To determine the disposition of extended release levetiracetam in normal dogs after single dosing. ANIMALS Pharmacokinetic study: 16 healthy, adult dogs. METHODS Using a partially randomized crossover study, levetiracetam (30 mg/kg) was administered intravenously (i.v.) and orally (p.o.) as extended release preparation with or… CONTINUE READING