Disposition mechanisms of raloxifene in the human intestinal Caco-2 model.

@article{Jeong2004DispositionMO,
  title={Disposition mechanisms of raloxifene in the human intestinal Caco-2 model.},
  author={Eun Ju Jeong and Huimin Lin and Ming Hu},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={310 1},
  pages={376-85}
}
The purpose of this study was to determine the mechanisms responsible for transport of raloxifene and its hydrophilic conjugates. Human intestinal Caco-2 cell culture model and Caco-2 cell lysate were used for the studies. The results indicated that absorptive permeability (PAB) of raloxifene was lower than its secretory permeability (PAB). As the concentration increased, the efflux ratio (PBA/PAB) decreased, but PBA increased. PAB was also increased in the presence of verapamil and… CONTINUE READING
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