Disposition in male volunteers of a subanaesthetic intravenous dose of an oil in water emulsion of 14C-propofol.

@article{Simons1988DispositionIM,
  title={Disposition in male volunteers of a subanaesthetic intravenous dose of an oil in water emulsion of 14C-propofol.},
  author={Paul Jonathan Simons and Ian Derek Cockshott and Evan J. Douglas and Elizabeth A. Gordon and Kristine Hopkins and Malcolm Rowland},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1988},
  volume={18 4},
  pages={
          429-40
        }
}
1. An intravenous dose of 14C-propofol (0.47 mg/kg) administered to six male volunteers was rapidly eliminated with 88% recovered in the urine in 5 days and less than 2% in faeces. 2. The dose was cleared by metabolism with less than 0.3% excreted unchanged. The major metabolites were the glucuronic acid conjugate of propofol and the glucuronic acid and sulphate conjugates of its hydroxylated derivative, 2,6-diisopropyl-1,4-quinol. Propofol glucuronide accounted for about 53% of the urinary… CONTINUE READING
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