Disposition and pharmacokinetics of naltrexone after intravenous and oral administration in rhesus monkeys.

@article{Reuning1989DispositionAP,
  title={Disposition and pharmacokinetics of naltrexone after intravenous and oral administration in rhesus monkeys.},
  author={Richard H. Reuning and S. B. Ashcraft and James N. Wiley and Bryant Morrison},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1989},
  volume={17 6},
  pages={583-9}
}
The purposes of this investigation were to determine the disposition of naltrexone (NTX) in monkeys and assess the role of first-pass metabolism and enterohepatic cycling in the disposition process. Concentrations of naltrexone and three metabolites were determined in plasma and urine as a function of time after po and iv NTX administration in six monkeys… CONTINUE READING