Disposition and pharmacodynamics of dichloroacetate (DCA) and oxalate following oral DCA doses.

@article{Curry1991DispositionAP,
  title={Disposition and pharmacodynamics of dichloroacetate (DCA) and oxalate following oral DCA doses.},
  author={Sarah H Curry and Andreas Lorenz and Paicheng Chu and Marian C. Limacher and Peter W. Stacpoole},
  journal={Biopharmaceutics & drug disposition},
  year={1991},
  volume={12 5},
  pages={375-90}
}
Healthy volunteers received intravenous and/or oral doses of sodium dichloroacetate (DCA) in various single and multiple dose regimens. A crossover bioavailability study proved abortive because second and subsequent doses showed significantly longer terminal elimination half-lives (means 3.64 h and 9.9 h, respectively) than was the case for initial doses (1.58 h). A parallel bioavailability comparison failed to show that oral doses were significantly different from 100 per cent bioavailability… CONTINUE READING

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