Corpus ID: 26000466

Disposition and metabolism of sodium 4-[(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl]-gamma -oxobenzenebutanoate in rats and dogs.

@article{Tocco1988DispositionAM,
  title={Disposition and metabolism of sodium 4-[(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl]-gamma -oxobenzenebutanoate in rats and dogs.},
  author={D. Tocco and F. Deluna and A. Duncan and H. Ramjit and S. Pitzenberger and J. Hsieh},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1988},
  volume={16 5},
  pages={
          690-6
        }
}

D. Tocco, F. Deluna, +3 authors J. Hsieh

Published 1988

Chemistry, Medicine

Drug metabolism and disposition: the biological fate of chemicals

The disposition of sodium 4-[(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl]-gamma-o xo benzenebutanoate (L-648,051) was determined in rats and dogs. L-648,051 is a potent receptor antagonist for leukotriene D4 and is potentially useful in the treatment of asthma and other allergic disorders. After a dosage of 10 mg/kg iv, L-648,051 declined rapidly with a half-life of approximately 2 min in rat and dog plasma. Although the compound was well absorbed, it exhibited poor bioavailability… CONTINUE READING

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