Disposition and metabolism of ralfinamide, a novel Na-channel blocker, in healthy male volunteers.

@article{Bauer2010DispositionAM,
  title={Disposition and metabolism of ralfinamide, a novel Na-channel blocker, in healthy male volunteers.},
  author={Martin Peter Bauer and Harald Bliesath and Chiara Leuratti and Edith Lackner and Walter Dieterle and Markus U. M{\"u}ller and Martin Brunner},
  journal={Pharmacology},
  year={2010},
  volume={86 5-6},
  pages={297-305}
}
Ralfinamide is an α-aminoamide derivative with ion channel blocking properties, acting both peripherally and centrally through different molecular targets important in pain control. Absorption, blood and plasma time courses, and urinary and faecal excretion of total radioactivity were assessed in 6 male healthy volunteers administered a single oral dose of 320 mg ¹⁴C-(S)-ralfinamide. Pharmacokinetics of the parent drug were investigated over 120 h, urinary and plasma metabolites up to 192 h… CONTINUE READING