Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers.

@article{Chen1991DispositionAM,
  title={Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers.},
  author={Zhengqiang Chen and Andrew Alexander Somogyi and Glenn Reynolds and Felix Bochner},
  journal={British journal of clinical pharmacology},
  year={1991},
  volume={31 4},
  pages={381-90}
}
1. The pharmacokinetics, metabolism and partial clearances of codeine to morphine, norcodeine and codeine-6-glucuronide after single (30 mg) and chronic (30 mg 8 h for seven doses) administration of codeine were studied in eight subjects (seven extensive and one poor metaboliser of dextromethorphan). Codeine, codeine-6-glucuronide, morphine and norcodeine were measured by high performance liquid chromatographic assays. 2. After the single dose, the time to achieve maximum plasma codeine… CONTINUE READING