Disposition and metabolic profiling of [(14)C]cerlapirdine using accelerator mass spectrometry.


Cerlapirdine (SAM-531, PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine and other 5-HT6 receptor antagonists have been in clinical development for the symptomatic treatment of Alzheimer's disease. A human absorption, distribution, metabolism, and excretion study was conducted to gain further… (More)
DOI: 10.1124/dmd.114.059675

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