Disposition and enterohepatic circulation of diclofenac in dogs.

  title={Disposition and enterohepatic circulation of diclofenac in dogs.},
  author={Toshie Tsuchiya and Mari Terakawa and Koji Ishibashi and Hiroshi Noguchi and Ryuichi Kato},
  volume={30 10},
Following i.v. administration of 14C-labelled 2-(2',6'-dichloroanilino) phenylacetic acid (14C-diclofenac) (25 mg/kg) to dogs, 65% of the dose of total radioactivity was excreted in the bile in the first 6 h. A trace of unchanged diclofenac and three metabolites were demonstrated in the bile by 2-dimensional TLC. Two of these metabolites were identified as diclofenac acyl-glucuronide (80% of total radioactivity in the bile) and taurine conjugate (10%); the third was an unknown metabolite (2… CONTINUE READING

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