Disposition Characteristics of Macromolecules in Tumor-Bearing Mice

@article{Takakura1990DispositionCO,
  title={Disposition Characteristics of Macromolecules in Tumor-Bearing Mice},
  author={Yoshinobu Takakura and Takuya Fujita and Mitsuru Hashida and Hitoshi Sezaki},
  journal={Pharmaceutical Research},
  year={1990},
  volume={7},
  pages={339-346}
}
As part of the strategy for the design of macromolecular carriers for drug targeting, the disposition characteristics of macromolecules were studied in mice bearing tumors that served as target tissues. Eight kinds of macromolecules including four polysaccharides and four proteins with different molecular weights and electric charges were used; tissue distribution and tumor localization after intravenous injection were studied. Pharmacokinetic analysis revealed that the tissue radioactivity… CONTINUE READING
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