Disposition, metabolism, and excretion of U-71038, a novel renin inhibitor peptide, in the rat.

@article{Greenfield1989DispositionMA,
  title={Disposition, metabolism, and excretion of U-71038, a novel renin inhibitor peptide, in the rat.},
  author={John C. Greenfield and Kathleen J. Cook and I A O'Leary},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1989},
  volume={17 5},
  pages={518-25}
}
The in vivo fate of U-71038 (Boc-Pro-Phe-N-MeHis-Leu psi [CHOHCH2] Val-Ile-(aminomethyl)pyridine), a potent renin inhibitor, was investigated in rats by single iv administration of tritium-labeled drug at a dose level of 5 mg/kg. The plasma concentrations of drug-related radioactivity diminished very rapidly during the first hour after dosing, with the initial concentrations measured at 2 min falling by more than 95% during the first 30 min. Estimates of the approximate half-life of this… CONTINUE READING

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